Seth Rogen writes and stars as Dale, a thirty year old process server (not a computer, even though it sounds like one) who dates a high school girl and has no friends. His life has no direction and he is clearly haunted by the knowledge that he should be doing more, but at the same time lacks any willpower to change anything.
He does at least, have a good relationship with his dealer though, which is why he is able to buy the titular Pineapple Express, a particularly potent and enjoyable variety of weed that is so exclusive, his dealer and he are pretty much the only two people with access to it in the whole city.
Unfortunately, while Dale is smoking his exclusive product, he witnesses a murder and is so surprised that he drops his joint and makes enough noise to alert the killers to his presence. All of which means he and his dealer (James Franco on excellent form) are now both traceable by the murderers.
Through a haze of paranoia and fuzzy thinking, the pair goes on the run from the police and the killers, and along the way they discover a thing or two about life, as movie characters are prone to do.
As you would expect from the Apatow camp, this film is very funny. For the most part it bubbles along nicely with enough decent gags to keep you amused, but also occasionally breaks out into some pretty hilarious stuff.
Unusually for a film of this type though, there is a lot of violence. Guns are waved about throughout; people are shot, tortured and generally have bits of their bodies removed. However, it's usually dealt with in a funny and light-hearted way, despite the occasional moment that will remind you of the seriousness of the violence. The laughs return quickly enough though, and this strange pattern definitely serves to mark this film out as slightly different.
You'd have to say this is another solid comedy from the Apatow team, and well worth watching, especially if you're into stoner movies or films that poke fun at action movies.